Dr. Moritz Urschbach (PostDoc)

Contact:

Lab: 2224.02.131

Office: 2224.02.135

Phone: 39-23873

 
 
 

Research Topic:

Supramolecular peptide-glycopeptide conjugate vaccines

Curriculum Vitae:

01/2023 - 04/2023 PostDoc in the group of Prof. Pol Besenius, JGU Mainz
11/2018 - 12/2022 Ph.D. student in the group of Prof. Pol Besenius, JGU Mainz
04/2018 - 09/2018 Master thesis in the group of Prof. Pol Besenius, JGU Mainz
2017 - 2018 Master of Science in Biomedical Chemistry, JGU Mainz
2017 Bachelor thesis in the group of Prof. Pol Besenius, JGU Mainz
2013 - 2017 Bachelor of Science in Biomedical Chemistry, JGU Mainz
2013 Abitur + Baccalauréat scientifique, Max-Slevogt-Gymnasium, Landau/Pfalz

 

Publications:

[11] MUC1 Glycopeptide Vaccine Modified with a GalNAc Glycocluster Targets the Macrophage Galactose C-Type Lectin on Dendritic Cells to Elicit an Improved Humoral Response.
A. Gabba*, R. Attariya, S. Behren, C. Pett, J.C. van der Horst, H. Yurugi, J. Yu, M. Urschbach, J. Sabin, G. Birrane, E. Schmitt, S.J. van Vliet‡, P. Besenius‡, U. Westerlind‡, P.V. Murphy‡,
J. Am. Chem. Soc. 2023, 24, 13027-13037. DOI: 10.1021/jacs.2c12843.
(§ joint senior authors)

[10] Impact of Sample History and Solvent Effects on Pathway Control in the Supramolecular Polymerisation of Au(I)-Metallopeptide Amphiphiles.
M. Thomas, V. Lewe, J. Kölsch, M. Urschbach, J. Erlenbusch, O.S. Stach, P. Besenius*,
Polym. Chem. 2023, 14, 1888-1892. DOI: 10.1039/d3py00053b.

[9] A Modular Platform of Carbohydrates-Modified Supramolecular Polymers Based on Dendritic Peptide Scaffolds.
L. Li§, L. Wu§, M. Urschbach, D. Straßburger, X. Liu, P. Besenius*, G. Chen*,
ACS Polym. Au 2022, 2, 478–485.DOI: 10.1021/acspolymersau.2c00032.  (Open Access)
(§ these authors contributed equally)

[8] Predicting the Supramolecular Assembly of Amphiphilic Peptides from Comprehensive Coarse-Grained Simulations.
S. Chakraborty§, C.M. Berač§, M. Urschbach, D. Spitzer, M. Mezger, P. Besenius, T. Speck*,
ACS Appl. Polym. Mater. 2022, 4, 822-831. DOI: 10.1021/acsapm.1c01208.
(§ these authors contributed equally)

[7] Bridging Rigidity and Flexibility: Modulation of Supramolecular Hydrogels by Metal Complexation.
O.S. Stach§, K. Breul§, C.M. Berač*, M. Urschbach, S. Seiffert*, P. Besenius*,
Macromol. Rapid Commun. 2022, in press. DOI: 10.1002/marc.202100473. (Open Access)
(§ these authors contributed equally)

[6] The Development of Vaccines from Synthetic Tumor-Associated Mucin Glycopeptides and their Glycosylation-Dependent Immune Response.
N. Stergiou*, M. Urschbach, A. Gabba, E. Schmitt, H. Kunz, P. Besenius*,
Chem. Rec. 2021, 21, 3313-3331. DOI: 10.1002/tcr.202100182.

[5] Cell Adhesion on UV-Crosslinked Polyurethane Gels with Adjustable Mechanical Strength and Thermoresponsiveness.
K. Breul§, E. Stengelin§, M. Urschbach, M. Mondeshki, L. Wüst, J. Sirleaf, S. Seitel, T. Emt, S. Pschierer, P. Besenius, S. Seiffert*,
Macromol. Rapid Commun.2021, 42, 2100505. DOI: 10.1002/marc.202100505.
(§ these authors contributed equally)
[4] Targeted Repolarization of Tumor-associated Macrophages via Imidazoquinoline-linked Nanobodies.
E. Bolli, M. Scherger, S.M. Arnouk, A.R. Pombo Antunes, D. Straßburger, M. Urschbach, J. Stickdorn, K. De Vlaminck, K. Movahedi, H.J. Räder, S. Hernot, P. Besenius, J.A. Van Ginderachter*, L. Nuhn*,
Adv. Sci. 2021, 8, 2004574. DOI: 10.1002/advs.202004574. (Open Access)

[3] Supramolecular Polymerisation of Sulfated Dendritic Peptide Amphiphiles into Multivalent L-Selectin Binders.
D. Straßburger, S. Herziger, K. Huth, M. Urschbach, R. Haag*, P. Besenius*,
Beilstein J. Org. Chem. 2021, 17, 97-104. DOI: 10.3762/bjoc.17.10. (Open Access)
Invited contribution to the thematic issue "Molecular recognition", dedicated to the memory of Prof. Carsten Schmuck.

[2] Evaluation of Charge-Regulated Supramolecular Copolymerization to Tune the Time-Scale for Oxidative Disassembly of ß-Sheet Comonomers.
C.M. Berač, L. Zengerling, D. Straßburger, R. Otter, M. Urschbach, P. Besenius*,
Macromol. Rapid Commun. 2019, 1900476, DOI: 10.1002/marc.201900476. (Open Access)
Invited contribution to '100 years of polymer research' special issue.

[1] Mannose-Decorated Multicomponent Supramolecular Polymers Trigger Effective Uptake into Antigen-Presenting Cells.
D. Straßburger, N. Stergiou, M. Urschbach, H. Yurugi, D. Spitzer, D. Schollmeyer, E. Schmitt*, P. Besenius*,
ChemBioChem 2018, 19, 912-916. DOI: 10.1002/cbic.201800114.
Cover Feature: ChemBioChem 2018, 19, 894. DOI: 10.1002/cbic.201800191.