Dr. Adele Gabba

Contact:

Lab: 2224.02.125

Office: 2224.02.135

Phone: 39-23873

 

Research Topic:

Supramolecular peptide-glycopeptide conjugate vaccines

Curriculum Vitae:

07/2020 - 02/2021 Postdoctoral researcher in the group of Prof. Pol Besenius, JGU Mainz
11/2019 - 03/2020 Research Assistant in the groups of Dr. Andrew Flaus & Professor Paul V. Murphy, Centre for Chromosome Biology, National University of Ireland Galway, Galway, Ireland
07/2019 - 08/2019 Postgraduate internship in the group of Prof. Jesús Jiménez-Barbero, CIC bioGUNE, Derio, Spain
01/2018 - 12/2018 Predoctoral research fellow in the group of Prof. Jerome Groopman, supervision by Dr. Gabriel Birrane, Harvard Medical School, Experimental Medicine, BIDMC X Ray Core, Boston, MA, USA
10/2017 - 11/2017 Postgraduate internship in the group of Prof. Ulrika Westerlind, ISAS, Dortmund, Germany
2015 - 2019 Ph.D. Candidate in chemistry, National University of Ireland Galway, Galway, Ireland
06/2015 - 09/2015 Research Assistant in the group of Prof. Paul V. Murphy, National University of Ireland Galway, Galway, Ireland
01/2015 - 06/2015 Postgraduate placement in the group of Prof. Andreas Kirschning, Leibniz University, Hannover, Germany
2014 Master thesis in the group of Prof. Gianluigi Broggini, supervision professor Daniele Passarella, University of Insubria, Como, Italy
04/2014 - 07/2014 Graduate internship in the group of Prof. Paul V. Murphy, National University of Ireland Galway, Galway, Ireland
2012 - 2014 Master of Science in Chemistry, University of Insubria, Como, Italy
2012 Bachelor thesis in the group of Prof. Gianluigi Broggini, University of Insubria, Como, Italy
2010 - 2015 Laboratory internship, University of Insubria, Como, Italy
2009 - 2012 Bachelor of Science in chemistry and industrial chemistry, University of Insubria, Como, Italy
2009 Baccalaureate in educational science, Liceo Vittorio Sereni, Luino, Italy

 

Publications:

[12] MUC1 Glycopeptide Vaccine Modified with a GalNAc Glycocluster Targets the Macrophage Galactose C-Type Lectin on Dendritic Cells to Elicit an Improved Humoral Response.
A. Gabba*, R. Attariya, S. Behren, C. Pett, J.C. van der Horst, H. Yurugi, J. Yu, M. Urschbach, J. Sabin, G. Birrane, E. Schmitt, S.J. van Vliet‡, P. Besenius‡, U. Westerlind‡, P.V. Murphy‡,
J. Am. Chem. Soc. 2023, 24, 13027-13037. DOI: 10.1021/jacs.2c12843.
(§ joint senior authors)

[11] Exploring the Galectin Network by Light and Fluorescence Microscopy.
G.G. Caballero, J.C. Manning, A. Gabba, D.M. Beckwith, F.G. FitzGerald, T.J. Kutzner, A.-K. Ludwig, H. Kaltner, P.V. Murphy, M. Cudic, H.-J. Gabius,
Methods Mol. Biol. 2022, 2442, 307–338. DOI: 10.1007/978-1-0716-2055-7_17.

[10] The Development of Vaccines from Synthetic Tumor-Associated Mucin Glycopeptides and their Glycosylation-Dependent Immune Response.
N. Stergiou*, M. Urschbach, A. Gabba, E. Schmitt, H. Kunz, P. Besenius*,
Chem. Rec. 2021, 21, 3313-3331. DOI: 10.1002/tcr.202100182.

[9] Imitating evolution’s tinkering by protein engineering reveals extension of human galectin-7 activity.
A.-K. Ludwig, M. Michalak, A. Gabba, T.J. Kutzner, D.M. Beckwith, F.G. FitzGerald, G.G. Caballero, J.C. Manning, M. Kriegsmann, H. Kaltner, P.V. Murphy, M. Cudic, J. Kopitz, H.-J. Gabius,
Histochem. Cell Biol. 2021,156, 253–272. DOI: 10.1007/s00418-021-02004-w.

[8] Probing sulfatide-tissue lectin recognition with functionalized glycodendrimersomes.
P.V. Murphy, A. Romero, Q. Xiao, A.-K. Ludwig, S. Jogula, N.V. Shilova, T. Singh, A. Gabba, B. Javed, D. Zhang, F.J. Medrano, H. Kaltner, J. Kopitz, N.V. Bovin, A.M. Wu, M.L. Klein, V. Percec, H.-J. Gabius,
iScience 2021, 24, 101919. DOI: 10.1016/j.isci.2020.101919.

[7] Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen.
A. Gabba, A. Bogucka, J. G. Luz, A. Diniz, H. Coelho, F. Corzana, F. J. Cañada, F. Marcelo, P. V. Murphy, G. Birrane,
Biochemistry 2021, 60, 1327–1336. DOI: 10.1021/acs.biochem.1c00009.

[6] Influence of protein (human galectin-3) design on aspects of lectin activity.
G. G. Caballero, D. Beckwith, N. V. Shilova, A. Gabba, T. J. Kutzner, A. Ludwig, J. C. Manning, H. Kaltner, F. Sinowatz, M. Cudic, N.V. Bovin, P. V. Murphy, H. J. Gabius,
Histochem. Cell Biol. 2020,154, 135–153. DOI: 10.1007/s00418-020-01859-9.

[5] How altering the modular architecture affects lectin activity: case study on human galectin-1.
T. J. Kutzner *, A. Gabba*, F. G. FitzGerald*, N. V. Shilova*, G. G. Caballero, A. Ludwig, J. C. Manning, C. Knospe, H. Kaltner, F. Sinowatz, P. V. Murphy, M. Cudic, N. V. Bovin, H. J. Gabius,
Glycobiology 2019, 29, 593-607. DOI: 10.1093/glycob/cwz034.

[4] Revealing biomedically relevant cell and lectin type-dependent structure-activity profiles for glycoclusters by using tissue sections as assay platform.
H. Kaltner, J. C. Manning, G. G. Caballero, C. Di Salvo, A. Gabba, L. Romero, C. Knospe, D. Wu, H. Daly, D. F. O’Shea, H. J. Gabius. P. V. Murphy,
RSC Adv. 2018, 8, 28716-28735. DOI: 10.1039/c8ra05382k.

[3] Anomer Preferences for Glucuronic and Galacturonic Acid and Derivatives and Influence of Electron-Withdrawing Substituents.
L. Kerins, S. Byrne, A.Gabba, P.V. Murphy,
J. Org. Chem. 2018, 83, 7714-7729. DOI: 10.1021/acs.joc.8b00610.

[2] Synthesis and Biological Evaluation of Migrastatin Macrotriazoles.
A.Gabba, S. Robakiewicz, B. Tacia, K. Ulewicz, G. Broggini, G. Rastelli, M. Krol, P. V. Murphy, D. Passarella,
Eur. J. Org. Chem. 2017, 60-69. DOI: 10.1002/ejoc.201600988.

[1] 1,2-Bis (diphenylphosphano) Ethane (DPPE)-Mediated Synthesis of Glycosyl Amides.
D. Temelkoff, P. Norris, A.Gabba,
Carbohydrate Chemistry Proven Synthetic Methods 2017, Vol. 4 & J. Carbohydr. Chem. 2018, 37 (3)  198-198. DOI: 10.1080/07328303.2018.1454795.