Dr. David Straßburger


Lab: 2224.02.131

Office: 2224.02.135

Phone: 39-23873


Research Topic:

Nanoscaled supramolecular peptide-glycopeptide conjugate vaccines

Curriculum Vitae:

11/2015 - 10/2018 Ph.D. student in the group of Prof. Pol Besenius, JGU Mainz
03/2015 - 10/2015 Master thesis in the group of Prof. Horst Kunz, JGU Mainz
Topic: synthetic glycopeptide vaccines
04/2014 - 10/2015 Master of Science in Biomedical Chemistry, JGU Mainz
08/2013 - 04/2014 DAAD-ISAP exchange student in the group of Prof. Gregory Tew,
University of Massachusetts, Amherst, USA
Topic: metal-containing polymers
08/2013 Bachelor thesis in the group of Prof. Horst Kunz, JGU Mainz
2010 - 2013 Bachelor of Science in Biomedical Chemistry, JGU Mainz
06/2010 - 10/2010 Research Internship, Boehringer Ingelheim RCV GmbH & Co KG, Vienna
09/2007 - 06/2010 Apprenticeship as lab assistant, Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim
2007 Abitur, Stefan George-Gymnasium, Bingen



[9] A Modular Platform of Carbohydrates-Modified Supramolecular Polymers Based on Dendritic Peptide Scaffolds.
L. Li§, L. Wu§, M. Urschbach, D. Straßburger, X. Liu, P. Besenius*, G. Chen*,
ACS Polym. Au 2022, 2, 478–485. DOI: 10.1021/acspolymersau.2c00032 (Open Access)
(§ these authors contributed equally)

[8] Targeted Repolarization of Tumor-associated Macrophages via Imidazoquinoline-linked Nanobodies.
E. Bolli, M. Scherger, S.M. Arnouk, A.R. Pombo Antunes, D. Straßburger, M. Urschbach, J. Stickdorn, K. De Vlaminck, K. Movahedi, H.J. Räder, S. Hernot, P. Besenius, J.A. Van Ginderachter*, L. Nuhn*,
Adv. Sci. 2021, 8, 2004574. DOI: 10.1002/advs.202004574. (Open Access)

[7] Supramolecular Polymerisation of Sulfated Dendritic Peptide Amphiphiles into Multivalent L-Selectin Binders.
D. Straßburger, S. Herziger, K. Huth, M. Urschbach, R. Haag*, P. Besenius*,
Beilstein J. Org. Chem. 2021, 17, 97-104. DOI: 10.3762/bjoc.17.10. (Open Access)
Invited contribution to the thematic issue "Molecular recognition", dedicated to the memory of Prof. Carsten Schmuck.

[6] Evaluation of Charge-Regulated Supramolecular Copolymerization to Tune the Time-Scale for Oxidative Disassembly of ß-Sheet Comonomers.
C.M. Berač, L. Zengerling, D. Straßburger, R. Otter, M. Urschbach, P. Besenius*,
Macromol. Rapid Commun. 2019, 1900476, DOI: 10.1002/marc.201900476.

[5] Synthetic MUC1 Antitumor Vaccine with Incorporated 2,3-Sialyl-T Carbohydrate Antigen Inducing Strong Immune Responses with Isotype Specificity.
D. Straßburger, M. Glaffig, N. Stergiou, S. Bialas, P. Besenius, E. Schmitt, H. Kunz*
ChemBioChem 201819, in press. DOI: 10.1002/cbic.201800148.

[4] Mannose-Decorated Multicomponent Supramolecular Polymers Trigger Effective Uptake into Antigen-Presenting Cells.
D. Straßburger, N. Stergiou, M. Urschbach, H. Yurugi, D. Spitzer, D. Schollmeyer, E. Schmitt*, P. Besenius*, ChemBioChem 201819, 912-916. DOI: 10.1002/cbic.201800114.
Cover Feature: ChemBioChem 2018, 19, 894. DOI: 10.1002/cbic.201800191.

[3] Tuneable Transient Thermogels Mediated by a pH- and Redox-Regulated Supramolecular Polimerization.
D. Spitzer, L.L. Rodrigues, D. Straßburger, M. Mezger, P. Besenius*,
Angew. Chem. 2017, 129, 15664-15669. DOI: 10.1002/ange.201708857.
Angew. Chem. Int. Ed.
2017, 56, 15461-15465. DOI: 10.1002/anie.201708857.

[2] Kinetic Control in the Temperature-Dependent Sequential Growth of Surface-Confined Supramolecular Copolymers.
S. Engel, D. Spitzer, L.L. Rodrigues, E.-C. Fritz, D. Straßburger, M. Schönhoff, B.J. Ravoo*, P. Besenius*,
Faraday Discuss. 2017, 204, 53-67. DOI: 10.1039/c7fd00100b.

[1] Enhanced immunogenicity of multivalent MUC1 glycopeptide antitumour vaccines based on hyperbranched polymers.
M. Glaffig, B. Palitzsch, N. Stergiou, C. Schüll, D. Straßburger, E. Schmitt, H. Frey, H. Kunz*,
Org. Biomol. Chem., 2015, 13, 10150-10154. DOI: 10.1039/c5ob01255d.

Chem. Asian J. 2014, 9, 2052